Myo-inositol analogs and methods for their use
AssigneeUniversity of Pittsburgh
InventorAlan P. Kozikowski
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Abstract
The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycle-dependent conditions. The present invention also provides novel myo-inositol analogs.
Claims18
A method for inhibiting the phosphatidylinositol cycle in a cell which comprises contacting said cell with a compound represented by the formula I:
- ##STR17## wherein:
- R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is each independently selected from the group consisting of OH, F, N.sub.3, NH.sub.2, SH, SeH, Cl, Br, I and CN;
- with the proviso:
- (i) four or five of said R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are OH;
- and
- (ii) if said R.sup.4, R.sup.5 or R.sup.6 is F, Cl, Br or I then four of the said R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are OH.
A method for treating phosphatidylinositol cycledependent conditions in a mammal which comprises administering to said mammal an inositol phosphate cycle inhibiting amount of a compound represented by formula I:
- ##STR18## wherein:
- R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is each independently selected from the group consisting of OH, F, N.sub.3, NH.sub.2, SH, SeH, Cl, Br, I and CN;
- with the proviso:
- (i) four or five of said R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are OH;
- and
- (ii) if said R.sup.4, R.sup.5 or R.sup.6 is F, Cl, Br or I then four of the said R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are OH.
Dependencies are inferred from the claim text.