Fecal occult blood test reagents
AssigneeLitmus Concepts, Inc.
InventorPaul J. Lawrence
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Abstract
An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with a chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.
Claims18
A developer composition for detecting iron protoporphyrins in a fecal specimen using a leuco dye indicator, comprising a solution of a hydroperoxide and a modulating compound, wherein he solution contains at least 50% by volume of a solvent for iron protoporphyrins, and wherein the modulating compound is an accelerator selected from the group consisting of chloroquine, quinacrine and mixtures thereof.
A developer composition for detecting iron protoporphyrins in a fecal specimen using a leuco dye indicator, comprising a solution of a hydroperoxide and a modulating compound, wherein the solution contains at least 50% by volume of a solvent for iron protoporphyrins, and wherein the modulating compound is an inhibitor selected from the group consisting of quinien, primaquine, quinidine, and mixtures thereof.
A developer composition for detecting iron protoporphyrins in a fecal specimen using a leuco dye indicator, comprising a solution of a hydroperoxide, an accelerator selected from the group consisting of chloroquine, quinacrine, and mixtures thereof, and an inhibitor selected from the group consisting of quinine, primaquine, quinidine, and mixtures thereof, wherein the solution contains at least 50% by volume of a solvent for iron protoporphyrins.
Dependencies are inferred from the claim text.