Induction of antibody response to solid tumors with anti-idiotype antibodies
OwnerHilary Koprowski, Dorothee Herlyn +1inventors
InventorsHilary Koprowski, Dorothee Herlyn, Elaine C. DeFreitas
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Abstract
A method of inducing an immunological response to solid tumors is provided wherein anti-idiotype antibodies presenting an internal image of a tumor or antigen are administered to a patient. Monoclonal anti-idiotype antibodies and immortal B lymphocytes that produce them are also provided.
Claims17
A method of stimulating production of antibodies which bind to an epitope on a solid tumor cell comprising:
- administering a monoclonal anti-idiotypic antibody which bears an internal image of an epitope present on a solid tumor cell to a human in an amount sufficient to stimulate the production of an anti-anti-idiotypic antibodies which immunoreact with said solid tumor cell epitope,
- wherein said monoclonal anti-idiotypic antibody immunoreacts through its paratope with a monoclonal antibody specific for said solid tumor cell epitope.
An immortalized B lymphocyte that produces a monoclonal anti-idiotypic antibody which bears the internal image of an epitope present on a solid tumor cell, wherein said anti-idiotypic antibody
- (a) immunoreacts with paratope of a monoclonal antibody specific for said solid tumor cell epitope;
- and
- (b) will induce formation of anti-anti-iodiotypic antibodies specific for said solid tumor cell epitope upon administration to a human.
A polyclonal antibody preparation comprising antibodies bearing the internal image of an epitope present on a solid tumor cell, wherein said anti-idiotypic antibodies
- (a) immunoreact through their paratopes with the paratope of a monoclonal antibody specific for said solid tumor cell epitope;
- and
- (b) induce formation of anti-anti-iodiotypic antibodies specific for said solid tumor cell epitope upon administration to a human;
- and wherein said polyclonal antibody preparation is substantially free from anti-isotype antibodies and is produced by immunizing a mammalian host with a monoclonal antibody specific for said solid tumor cell epitope.
A method of stimulating production of antibodies which bind to an epitope on a solid gastrointestinal tumor comprising:
- administering a monoclonal anti-idiotypic antibody which bears an internal image of an epitope present on a solid gastrointestinal tumor cell to a human in an amount sufficient to stimulate the production of an anti-anti-idiotypic antibodies which immunoreact with said solid gastrointestinal tumor cell epitope,
- wherein said monoclonal anti-idiotypic antibody immunoreacts through its paratope with a monoclonal antibody specific for said solid gastrointestinal tumor cell epitope.
Dependencies are inferred from the claim text.