Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
AssigneeNorian Corporation
InventorsBrent R. Constantz, Bryan Barr, Kevin McVicker
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Abstract
Novel compositions are provided for the production of hydroxyapatite, where a dry mixture is provided which combines a calcium source and an acidic phosphate source, particularly monocalcium phosphate monohydrate or orthophosphoric acid crystals. These two are combined, optionally with other ingredients, with mechanical mixing, resulting in partial reaction or intimate combination to produce a product which requires less water for formation of a desired viscosity, has enhanced mechanical properties and is physilogically acceptable.
Claims18
In a method of preparing a product for preparation of a calcium phosphate mineral product, the improvement which comprises:
- mechanically mixing under reaction causing conditions as reactants at least one calcium source and an acidic phosphate source free of uncombined water for sufficient time for partial reaction of said calcium source and acidic phosphate source,
- whereby a dry product is produced for combination with a lubricant to form a solid product with substantially complete reaction of said reactants.
In a method of preparing a product for preparation of a hydroxyapatite product, the improvement which comprises:
- mechanically mixing with milling under reaction causing conditions reactants tetracalcium phosphate and an acidic phosphate source free of uncombined water for sufficient time for at least five weight percent of said tetracalcium phosphate and acidic phosphate source to react,
- whereby a dry product is produced for combination with a lubricant to form a solid hydroxyapatite product with substantially complete reaction of said reactants.
Dependencies are inferred from the claim text.