Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides
AssigneeOrtho Pharmaceutical Corporation
InventorsWilliam V. Murray, Michael P. Wachter
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Abstract
2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.
Claims3
A compound of the formula ##STR23## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are individually selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, amino, acetamido, phenyl, halo, hydroxy, lower alkylsulfonyl, lower alkylthio, nitro, trifluoromethyl, .omega.-trifluoromethyl lower alkoxy, or R.sub.1 R.sub.2 or R.sub.3 R.sub.4 taken together with the phenyl group to which they are attached, form a naphthyl or substituted naphtyl group wherein the substituent is halo, lower alkyl or lower alkoxy;
- R.sub.5, and R.sub.7 are the same or different and are individually selected from the group consisting of hydrogen, lower alkyl;
- R.sub.6 and R.sub.8 taken together are part of a ring selected from the group consisting of a cyclohexyl, cyclohexenyl and a 7-oxobicyclo [2.2.1] heptenyl ring, R.sub.9 is selected from hydroxy, --OR.sub.10 or --N(OH)R.sub.10 wherein R.sub.10 is lower alkyl;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.