Loading patent…
AssigneeResearch Development Foundation
InventorsJack V. Knight, Brian E. Gilbert, Samuel Z. Wilson, Howard R. Six, Philip R. Wyde
Estimating the term…
Disclosed are aqueous aerosol droplets containing liposome or interacted liposome-drug or medication combination particles in a continuous phase of air or oxygen-enriched air advantageous for the treatment of a wide variety of diseases. The drug or medication is interacted with the liposome membrane so that on its rupture the drug or medication is not lost from the liposome. Different methods of preparation of the aerosol particles containing the liposome and interacted liposome-drug combination particles are described which can be used in small particle aerosol treatment. The majority of the aerosol droplets containing the liposome particles alone or with drugs has a diameter less than 5 microns and has an aerodynamic mass median diameter ranging from about 1 to 3 microns, and the liposome and interacted-liposome drug particles are substantially uniform in size and less than 1 micron in diameter.
Aqueous aerosol droplets containing one or more liposome particles, the majority of the mass of the aerosol droplets having a diameter from 1 to 5 microns, and having an aerodynamic mass median diameter ranging from about 1 to 3 microns, the liposome particles being substantially homogeneous in size and having a diameter of less than 1 micron thereby providing deposition of the droplets containing the one or more liposome particles throughout a respiratory tract of a patient when inhaled.
Aqueous aerosol droplets containing one or more liposome particles and one or more lipophilic medications interacted with the liposome's membrane, the majority of the mass of the aerosol droplets having a diameter from 1 to 5 microns, and having an aerodynamic mass median diameter ranging from about 1 to about 3 microns, the particles being substantially homogenous in size and having a diameter of less than 1 micron thereby providing deposition of the droplets containing the one or more liposome particles through out a respiratory tract of a patient when inhaled.
Aqueous aerosol droplets containing one or more liposome particles having multiple aqueous compartments and one or more lipophilic medications interacted with membranes of the liposome particles, the majority of the mass of the aerosol droplets having a diameter of from 1 to 5 microns, and having an aerodynamic mass median diameter ranging from about 1 to about 3 microns, the particles being substantially homogeneous in size and having a diameter of less than 1 micron thereby providing deposition of the droplets containing the one or more liposome particles throughout a respiratory tract of a patient when inhaled.
Dependencies are inferred from the claim text.