Compositions and methods for treating skin conditions and promoting wound healing
AssigneeJohn Morris Co., Inc.
InventorsJohn Rothman, Philip A. Band
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Abstract
This invention relates to activated protein-containing compositions comprising reducing agents, oxidizing agents and/or anti-oxidants and methods of use. The therapeutic compositions and methods of the present invention are particularly effective in promoting wound healing, and in inhibiting certain skin disorders, including eczema and seborrhea, sclerodema and acne. The therapeutic compositions and methods of the present invention have also shown enhanced effect as veterinary tools in reducing the debilitation associated with certain skin conditions in mammals including eczematoid dermatitis, chronic dermatitis, equine exuberant granuloma ("proud flesh"), decubitis ulcers, and canine cutaneous granulomas ("lick" granuloma).
Claims34
A method for treating abnormal or damaged conditions of the epithelium, including skin, and ungual tissue comprising applying to the affected area a composition comprising:
- a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue;
- b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein;
- c). about 0.001 to about 4.0% by weight of an oxidizing agent capable of oxidizing cysteine to cystine;
- and
- d). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
A method for treating abnormal or damaged conditions of the epithelium including skin, and ungual tissue comprising applying to the affected area a composition comprising:
- a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue;
- b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein;
- and
- c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
A composition for treating acne comprising:
- (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to the skin or scalp;
- (b) about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein;
- (c) at least about 73% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents;
- and
- (d) an effective amount of an anti-acne agent.
A composition for treating wounds and damaged conditions of the epithelium, including skin comprising:
- (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to a wounded area or the skin selected from the group consisting or ribonuclease T1, human serum albumin, and fibrinogen and its derivatives;
- (b) about 0.1% to about 15% by weight of a reducing agent capable of reducing cystine groups to cysteine groups;
- and
- (c) about 73% to about 99.98% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents.
A method for diminishing the effects of acne scars in the skin comprising applying to the scarred area a composition comprising:
- a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to the skin;
- b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein;
- and
- c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Dependencies are inferred from the claim text.