Mucoadhesive carrier for delivery of therapeutical agent
AssigneeWatson Laboratories, Inc.
InventorsDilip R. Sanvordeker, Sau-Hung S. Leung
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Abstract
A mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a Monolithic polymer matrix that is anhydrous but hydratable, and amorphous fumed silica. The silica enhances the mucoadhesive properties of the carrier. An optional water-insoluble barrier film or layer can be secured to the polymer matrix to provide a non-adhering face.
Claims11
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 4,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:4, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being nifedipine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of nifedipine to said polyethylene glycol being about 1:2, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being piroxicam, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of piroxicam to said polyethylene glycol being about 1:2, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being albuterol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of albuterol to said polyethylene glycol being about 1:2, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:2, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being phenylpropanolamine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of phenylpropanolamine to said polyethylene glycol being about 1:2, respectively.
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face;
- said therapeutic agent being 17 .beta.-estradiol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of 17 .beta.-estradiol to said polyethylene glycol being about 1:2, respectively.
Dependencies are inferred from the claim text.