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US 5,045,533 AGranted
Retinoic esters of antibiotics and pharmaceutical and cosmetic compositions containing them
AssigneeL'oreal
InventorsMichel Philippe, Henri Sebag, Didier Dupuis, Andre Rougier
Life of this patent
Estimating the term…
Abstract
All trans or 13-cis retinoic acid esters of macrolide and lincosamide antibiotics. These esters are useful in the therapeutic and cosmetic treatment of dermatosis and principally in the treatment of acne.
Claims12
An all trans or 13-cis retinoic ester of a macrolide or lincosamide having the formula ##STR8## wherein R represents a macrolide selected from the group consisting of:
- erythromycin A substituted in the 2' position,
- roxithromycin substituted in the 2' position,
- oleandomycin substituted in the 2' position,
- oleandomycin substituted in the 4" position,
- oleandomycin substituted in the 2' and 4" positions,
- josamycin substituted in the 9 position,
- josamycin substituted in the 2' position,
- josamycin substituted in the 9 and 2' positions,
- spiramycin (I) substituted in the 2' position,
- spiramycin (I) substituted in the 4" position,
- spiramycin (I) substituted in the 2' and 4" positions,
- spiramycin (II) substituted in the 2' position,
- spiramycin (II) substituted in the 4" position,
- spiramycin (II) substituted in the 2' and 4" positions,
- spriamycin (III) substituted in the 2' position,
- spiramycin (III) substituted in the 4" position,
- spiramycin (III) substituted in the 2' and 4" positions,
- or R represents a lincosamide selected from the group consisting of
- lincomycin substituted in the 3 position,
- clindamycin substituted in the 3 position,
- lincomycin substituted in the 2, 4 and 7 positions and
- clindamycin substituted in the 2 and 4 positions.
19 more elements
Dependencies are inferred from the claim text.