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AssigneeDionex Corporation
InventorsPurnendu K. Dasgupta, Douglas L. Strong, John R. Stillian, Keith A. Friedman
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A method and apparatus has been provided for generating a high purity aqueous stream with selected ionic species--either cation (e.g. sodium) or anion (e.g. sulfate) and suitable for use as a chromatography eluent. In one form, an eluent generating means defines a source channel and a product channel separated by a permselective ion exchange membrane including exchangeable ions of the same charge as the selected ionic species. The membrane allows passage of ions of the same charge as the ionic species but is resistant to transmembrane passage of ions of opposite charge. Means is provided for applying an electrical potential between the source channel and product channel. In another form of the device, two different membranes define two source channels, a positively charged, anode source channel and a negatively charged cathode source channel, and a product channel. The effluent from the product channel is directed to the chromatographic separation means. Means is also provided for supplying liquid sample to the chromatographic separation means.
Apparatus suitable for generating a high purity, aqueous product stream including one or more selected ionic species and using it as a chromatography eluent, comprising eluent generating means defining a source channel and a product channel, and comprising a permselective ion exchange membrane partitioning said source channel and product channel, said ion exchange membrane including exchangeable ions of the same charge as said selected ionic species and allowing transmembrane passage to ions of the same charge as said exchangeable ions and being resistant to transmembrane passage of ions of the opposite charge, means for applying an electrical potential between said source channel and product channel, chromatographic separating means, conduit means for directing aqueous product stream from said product channel to said chromatographic separation means, and means for supplying a liquid sample to said chromatographic separating means.
A method of generating a high purity, aqueous product stream including one or more selected ionic species and using it as a chromatography eluent comprising the steps of
A method of generating a high purity, aqueous product stream including one or more selected ionic species and using it as a chromatographic eluent comprising the steps of
A method of generating a high purity, aqueous product stream including one or more selected ionic species and using it as a chromatographic eluent comprising the steps of
Dependencies are inferred from the claim text.