Method of preparing a freeze-dried formulation containing a drug
AssigneeSankyo Company, Limited
InventorsSeigo Ueda, Kunio Hashi, Takashi Shiokari, Akira Kusai
Life of this patent
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Abstract
In a freeze-drying method for producing a dried pharmaceutical compound or preparation, a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains said pharmaceutical compound of preparation dissolved or suspended therein. The other liquid or liquids may be pure solvent (generally water) or may contain one or more other substances.
Claims34
A method of preparing a freeze-dried preparation in which a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10.degree. C. to -50.degree. C., a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10.degree. C. to -50.degree. C., a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon to a temperature of from -10.degree. C. to -50.degree. C., a third aqueous liquid is added to the frozen first and second liquids without melting the frozen first and second liquids and is frozen thereon, and the frozen first, second and third liquids are freeze-dried together, in which at least one of said first, second and third liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Dependencies are inferred from the claim text.