Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
AssigneeSymphar S.A.
InventorsLan Nguyen, Eric Niesor, Hieu Phan, Pierre Maechler, Craig Bentzen
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Abstract
The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.
Claims16
Phenol substituted gem-diphosphonate derivatives of formula (I):
- ##STR35## where Z.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 identical or different are
- OR where R is H, or a straight or branched alkyl group comprising from 1 to 4 carbon atoms,
- or where Z.sup.1 with Z.sup.2 or Z.sup.3 with Z.sup.4 may form an alkyldienedixoy ring comprising from 3 to 5 carbon atoms,
- X.sup.1, X.sup.2 identical or different, are a straight or branched alkyl group from 1 to 4 carbon atoms,
- A is S, (CH.sub.2).sub.n, or (CH.dbd.CH).sub.k --CH.dbd. where n is an integer from 1 to 3, and k is zero is 1,
- B is H, or an alkyl group from 1 to 2 carbon atoms,
- t is zero or 1, with the proviso that t is zero only when A is (CH.dbd.CH).sub.k --CH.dbd. where k is as described above.
Phenol substituted alkylidene diphosphonates of formula (Ia) according to claim 34 ##STR36## were X.sup.1, X.sup.2, B, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 are as described in claim 1 and A is S or (CH.sub.2).sub.n where n is an integer from 1 to 3.
Phenol substituted alkenylinene diphosphonates of formula (Ib) according to claim 1 ##STR37## where X.sup.1, X.sup.2, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 are as described in claim 34 and k is zero or 1.
Dependencies are inferred from the claim text.