Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them
AssigneeIndena S.p.A.
InventorsEzio Bombardelli, Gian F. Patri
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Abstract
Complex compounds of flavonoids with phospholipids, characterized by high lipophilia and improved bio-availability and therapeutic properties as compared with free, not complexed flavonoids. The complex compounds of the invention are suitable for use as the active principle in pharmaceutical and cosmetic compositions.
Claims18
A complex of a flavonoid with a phospholipid wherein the flavonoid is a member selected from the group consisting of quercetin, kaempferol, quercetin-3-ramnoglucoside, quercetin-3-ramnoside, quercetin-3-glucoside, hyperoside, (+) apigenin, apigenin-7-glucoside, luteolin, luteolin-glucoside ramnoglucoside, 5,7,3',4'-pentahydroxy-flavone-3D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-tran scoumaroyl-)glucopyranoside, 3,4,5,4'-tetrahydroxy-flavone-3-D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-tran s-coumaroyl-)glucopyranoside, Ginkgonetine, Isoginkgonetine, Sciedopitasine, rutine and Bilobetine, and the phospholipid is a member selected from the group consisting of soy lecithins, egg lecithin phospholipids from bovine or swine brain or dermis, phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine in which the acyl groups are the same or different and are derived from palmitic, stearic, oleic, linoleic, linolenic acid, and wherein the phospholipid to flavonoid ratio is in the molar range from 0.5 to 2M.
Dependencies are inferred from the claim text.