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US 5,039,805 AGranted
Novel benzoic and phenylacetic acid derivatives
AssigneeHoffmann-La Roche Inc.
InventorsLeo Alig, Albrecht Edenhofer, Marcel Muller, Arnold Trzeciak, Thomas Weller
Life of this patent
Estimating the term…
Abstract
The compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and arteriosclerosis as well as for the treatment of tumours.
Claims3
A compound of formula ##STR11## wherein R.sup.e is H or amidino;
- R.sup.2 is H, CH.sub.3, OCH.sub.3, NO.sub.2, halogen, NH.sub.2, --NHCO--phenylene--COOH, --NHCO(CH.sub.2).sub.1-4 --COOH, OR.sup.h, --CH.sub.2 CH.sub.2 OR.sup.h, --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OR.sup.h or --CH.sub.2 COOR.sup.h wherein
- R.sup.h is H or lower alkyl;
- R.sup.3 is H, --CONH.sub.2, --COR.sup.f, --COOR.sup.g or aryl wherein R.sup.f is the residue of an .alpha.-aminocarboxylic acid attached via the amino group or an ester or amide thereof, and R.sup.g is H or lower alkyl.
Dependencies are inferred from the claim text.