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US 5,039,789 AGranted
A54145 cyclic peptides
AssigneeEli Lilly and Company
InventorsDavid S. Fukuda, Jon S. Mynderse
Life of this patent
Estimating the term…
Abstract
A new group of cyclic peptides, the A54145 cyclic peptides, which have the general formula: ##STR1## wherein: R is selected from the group consisting of hydrogen, an amino-protecting group, 8-methylnonanoyl, 8-methyldecanoyl and n-decanoyl; (Lys-R.sup.1) represents --NH(CH.sub.2).sub.4 CH(NHR.sup.1)CO--; R.sup.1 is hydrogen or an amino-protecting group; X is Ile or Val: and Y is Glu or 3-MG; provided that R.sup.1 cannot be hydrogen when R is 8-methylnonanoyl, 8-methyldecanoyl or n-decanoyl; and their salts are useful intermediates in the preparation of anitbacterial agents.
Claims18
A compound of the formula:
- ##STR14## wherein:
- R-Trp represents a group of formula:
- ##STR15## R is selected from the group consisting of hydrogen, an amino-protecting group, 8-methylnonanoyl, 8-methyldecanoyl and n-decanoyl;
- (Lys-R.sup.1) represents --NH(CH.sub.2).sub.4 CH(NHR.sup.1)CO--;
- R.sup.1 is hydrogen or an amino-protecting group;
- X is Ile or Val;
- and
- Y is Glu or 3-MG;
- provided that R.sup.1 cannot be hydrogen when R is 8-methylnonanoyl, 8-methyldecanoyl or n-decanoyl;
- or a pharmaceutically-acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.