Antiinflammatory PLA.sub.2 inhibitors

A substituted benzylamine phospholipase A.sub.2 inhibitor of the formula:

• ##STR155## or a pharmaceutically acceptable salt thereof, wherein Ar is ##STR156## and Z is H, F, Cl, Br, --OR.sup.1, or --S(O).sub.m R.sup.1, where R.sup.1 is H, --CH.sub.3, or --C.sub.2 H.sub.5, and m is 0, 1, or 2;
• n is 1 to 5;
• X is NH;
• and
• R is C.sub.7 -C.sub.25 alkyl, or a mono- or polycyclic benzoid aromatic system of the formula:
• ##STR157## where W is C.sub.1 -C.sub.20 alkyl, F, Cl, Br, --OR.sup.2, --S(O).sub.q R.sup.2, --C(CF.sub.3).sub.2 OH, or phenyl, and R.sub.2 is --CH.sub.3 or --C.sub.2 H.sub.5, and q is 0, 1, or 2;
• or
• R is benzhydryl, alkaryl or substituted alkaryl of 7 to 25 carbon atoms, where the substitution is on the aromatic moiety, and is F, Cl, Br, --OR.sup.3, --S(O).sub.r R.sup.3, or C.sub.1 -C.sub.10 alkyl, where R.sup.3 is --CH.sub.3 or --C.sub.2 H.sub.5, and r is 0, 1, or 2;
• provided that:
• a) when Z is H, X is NH, and n is 2, then R cannot be benzhydryl;
• b) when X is NH, then R cannot be phenyl or benzyl.