Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsLarry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
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Abstract
This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently chosen from straight chain and branched chain C.sub.1 -C.sub.12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl groups; or R.sub.1 and R.sub.2 together with the nitrogen atom they are bonded to form a pyrrolidino, piperidino, piperazino or morpholino group, M.sup.+ is a pharmaceutically acceptable cation, wherein X is the valence of the cation.
Claims14
A sterile pharmaceutical composition useful in the treatment of hypertension comprising:
- an effective amount of a compound of the formula ##STR5## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of a straight chain or branched chain C.sub.1 -C.sub.12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom, M.sup.+X is a pharmaceutically acceptable cation, wherein x is the valence of the cation;
- and a pharmaceutically acceptable carrier therefor.
A method of treating hypertension in mammals which comprises administering to a mammal, in need thereof, a blood pressure lowering effective amount of a compound of the formula:
- ##STR6## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of a straight chain or branched chain C.sub.1 -C.sub.12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom;
- and M.sup.+X is a pharmaceutically acceptable cation, wherein x is the valence of the cation.
The method of claim 16 wherein R.sub.1 and R.sub.2 are independently selected from C.sub.2 -C.sub.6 alkyl groups.
Dependencies are inferred from the claim text.