Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
AssigneeNeophore Technologies, Inc.
InventorBernard Ecanow
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Abstract
A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid comprising an interim skeletal structure of a water-soluble, hydratable gel or foam forming material, preferably a proteinaceous material, such as gelatin, that has been hydrated, rigidified, such as with maltodextrin, in the hydrated state and dehydrated to leave spaces in place of hydration water. On dissolution by saliva, bodily fluids or other liquids. The composition becomes a liquid system. While the oral route is preferred, other routes may be used to administer the compositions of this method.
Claims12
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising the steps of:
- (a) freezing a hydrated solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material;
- (b) contacting the frozen material of step (a) with the active material in an amount sufficient to cause the active material to be absorbed or absorbed within the frozen material;
- (c) dehydrating the frozen material from step (b) by causing material transfer of water from the frozen material to an organic liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0.degree. C. or below;
- and
- (d) removing the organic liquid solvent from the dehydrated material resulting from step (c).
Dependencies are inferred from the claim text.