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US 5,034,506 AGranted
Uncharged morpholino-based polymers having achiral intersubunit linkages
AssigneeAnti-Gene Development Group
InventorsJames E. Summerton, Dwight D. Weller
Life of this patent
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Abstract
A polymer composition is disclosed composed of morpholino subunit structures which are linked together by uncharged, achiral linkages. These linkages are one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
Claims13
A polymer composition comprised of morpholino subunit structures of the form:
- ##STR2## where (i) the structures are linked together by uncharged, achiral linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5' , exocyclic carbon of an adjacent subunit, and (ii) P.sub.i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Dependencies are inferred from the claim text.