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US 5,032,675 AGranted
Process for the production of glutamine derivatives
AssigneeAjinomoto Co., Inc.
InventorsToshihisa Kato, Masahiko Kurauchi
Life of this patent
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Abstract
Improved methods for synthesizing glutamine-containing peptides, involving an active ester method between a protected, C-terminal activated amino acid or a protected, C-terminal activated peptide, and unprotected glutamine in the presence of a weak base, are disclosed.
Claims5
In a process for producing a peptide containing an L-, D- or DL-glutamine residue through formation of a peptide bond between the C-terminus of an N-protected amino acid or the C-terminus of an N-protected peptide and the N-terminus of glutamine by way of an active ester intermediate for peptide synthesis, the improvement which comprises:
- forming said peptide bond in the presence of a weak base, by reacting an unprotected L-, D-, or DL-glutamine as a reactant with an active ester of said N-protected amino acid or peptide.
Dependencies are inferred from the claim text.