Continuous hemodialysis using citrate
AssigneeThe Regents of the University of California
InventorsDavid M. Ward, Ravindra L. Mehta
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Abstract
The present invention provides a method of preventing blood from clotting in a filter during continuous arteriovenous or venovenous hemodialysis on a patient comprising administering to the blood an amount of citrate sufficient to prevent clotting in the filter. The invention preferably utilizes a dialysate having a sodium and calcium concentration below that of normal blood and an alkali concentration sufficiently low to reduce or prevent alkalosis.
Claims18
A method of preventing blood from clotting in a filter during continuous arteriovenous or venovenous hemodialysis on a patient comprising continuously administering to the blood which has been drawn from the patient and has not yet entered the filter an effective anti-clotting amount of sodium citrate sufficient to prevent clotting in the filter and a dialysate comprising sodium at a concentration between about 77 and 130 mEq/1, alkali at a concentration below about 25 mEq/1, calcium at a concentration below that of blood, and wherein the dialysate flow rate is less than about 6,000 ml/hr.
A dialysate solution comprising a sodium concentration between about 77 and 130 mEq/1, a calcium concentration below that of blood, and an alkali concentration below about 25 mEq/1.
Dependencies are inferred from the claim text.