Gas chromatography methods and apparatus
AssigneeUniversity of Dayton
InventorWayne A. Rubey
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Abstract
Gas chromatographic methods and apparatus are disclosed whereby improved separation times and efficiency are achieved by provision of a rapid transfer of heat or cooling from a heating or cooling source to the chromatographic column. The column is provided within an insulating sheath. A resistance heating element disposed in the sheath and optional heated or cooling gas flow through the sheath is capable of rapdily changing the temperature imparted to the column thereby.
Claims33
Method of performing gas chromatographic analysis wherein a sample is admitted to a chromatographic column and caused to travel in a direction from upstream to downstream from an inlet port of said column to an elution port, comprising the steps of
- (a) providing temperature control means in thermal transfer relation with said column, said temperature control means being adapted to heat or cool said column to a desired temperature, and
- (b) transferring desired temperature changes of at least about 0.5.degree. C. per second from said temperature control means to said column.
Gas chromatographic apparatus of the type adapted to perform sample separation analysis comprising
- (a) an open tubular chromatographic column having a sample inlet port located at an upstream portion of said column and a sample elution port at a downstream portion of said column,
- (b) temperature control means in thermal transfer relation with said column for imparting a desired temperature to said column, said column (a), and temperature control means (b) being capable of transferring changes of at least about 0.5.degree. C. per second from said temperature control means to said column.
Gas chromatographic apparatus comprising an open tubular chromatographic column having an upstream sample inlet port and a downstream sample elution port, a heater in thermal transfer relation with respect to said column, fluid regulating means for passing a heat exchange fluid into heat exchange relation with said column, said heater being operatively connected to a time and temperature control programmer and said fluid regulating means being operatively connected to a time and flow rate regulator.
Dependencies are inferred from the claim text.