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US 5,023,269 AGranted
3-aryloxy-3-substituted propanamines
AssigneeEli Lilly and Company
InventorsDavid W. Robertson, David T. Wong, Joseph H. Krushinski, Jr.
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Abstract
The present invention provides 3-aryloxy-3-substituted propanamines capable of inhibiting the uptake of serotonin and norepinephrine.
Claims51
A compound of the formula ##STR82## wherein:
- R.sup.1 is thienyl, halothienyl, (C.sub.1 -C.sub.4 alkyl)thienyl, furanyl, pyridyl or thiazolyl;
- ##STR83## each of R.sup.2 and R.sup.3 independently is hydrogen or methyl;
- each R.sup.4 independently is halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy or trifluoromethyl;
- each R.sup.5 independently is halo, C.sub.1 C.sub.4 alkyl or trifluoromethyl;
- m is 0, 1 or 2;
- n is 0 or 1;
- and
- the pharmaceutically acceptable acid addition salts thereof.
5 more elements
The compound of claim 10 which is N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, and its pharmaceutically acceptable acid addition salts.
The compound of claim 11 which is the (+) stereoisomer.
The compound of claim 12 which is (+)-N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate.
A method of claim 38 wherein R.sup.1 is thienyl.
Dependencies are inferred from the claim text.