Hydrogenated rapamycin derivatives
AssigneeAmerican Home Products Corporation
InventorsCraig E. Caufield, John H. Musser, James M. Rinker
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Abstract
A derivative of rapamycin where one, two, or three of the double bonds at the 1-,3-, or 5-positions of rapamycin have been reduced to the corresponding alkane, or a pharmaceutically acceptable salt thereof, which by virtue of its antifungal activity is useful in treating fungal infections. ##STR1##
Claims6
A derivative of rapamycin where one, two, or three of the double bonds at the 1-, 3-, or 5-positions of rapamycin have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
A method of treating fungal infections by administering an effective amount of a compound which is a derivative of rapamycin in which one, two, or three of the double bonds at the 1-, 3-, or 5-positions have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.