Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
AssigneeAphton Corporation
InventorsPhilip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
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Abstract
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
Claims8
An immunogenic composition comprising a peptide selected from the group consisting of pGlu-Gly-Pro-Trp-Leu-Glu-Glu-GLu, pGlu-Gly-Pro-Trp-Leu-Glu-Glu, pGlu-Gly-Pro-Trp-Leu-Glu-, pGlu-Gly-Pro-Trp-Leu, pGlu-Gly-Pro-Trp" to "pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu, pGlu-Gly-Pro-Trp-Leu-Glu-Glu, pGlu-Gly-Pro-Trp-Leu-Glu, pGlu-Gly-Pro-Trp-Leu, pGlu-Gly-Pro-Trp", coupled to an immunogenic carrier.
An immunogenic composition comprising a plurality of peptide monomers wherein each peptide monomer is selected from the group consisting of pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu, pGlu-Gly-Pro-Trp-Leu-Glu-Glu, pGlu-Gly-PRo-Trp-Leu-Glu, pGlu-Gly-Pro-Trp-Leu, pGlu-Gly-Pro-Trp said monomers being crosslinked to each other by means of crosslinking agent so as to form a polymer.
Dependencies are inferred from the claim text.