Paramagnetic/superparamagnetic/ferromagnetic sucrose sulfate compositions for magnetic resonance imaging of the gastrointestinal tract
AssigneeUniversity of New Mexico
InventorKenneth T. Cheng
Life of this patent
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Abstract
The disclosure is directed to a sucrose sulfate composition useful for magnetic resonance imaging of the gastrointestinal tract. Paramagnetic/superparamagnetic/ferromagnetic ions or particles are attached to sucrose sulfate molecules in the composition. The sucrose sulfate composition travels, in the patient, to sites in the gastrointestinal tract which are diseased and the paramagnetic/superparamagnetic/ferromagnetic ions or particles allow magnetic resonance imaging to be more effective for imaging of these sites in the gastrointestinal tract.
Claims15
A composition useful for administration to a patient as an image contrast agent for selective identification of diseased sites in the gastrointestinal tract by magnetic resonance imaging, comprising a sucrose sulfate labeled with at least one member selected from the group consisting of paramagnetic ions, superparamagnetic particles, and ferromagnetic particles.
The sucrose sulfate composition of claim 76 wherein said paramagnetic ions are insoluble and comprise at least one member selected from the group consisting of ron carbonate (FeCO.sub.3), iron silicide (FeSi), iron diphosphide (Fe.sub.2 P), iron disulfide (FeS.sub.2), chromium mononitride (CrN), gadolinium oxalate (Gd.sub.2 (C.sub.2 O.sub.4).sub.3.10H.sub.2 O), gadolinium acetylaacetonate trihydrate (Gd(CH(COCH.sub.3).sub.2).sub.3.3H.sub.2 O), gadolinium oxide (Gd.sub.2 O.sub.3), copper oleate (Cu(C.sub.18 H.sub.33 O.sub.2).sub.2), and copper xanthate (Cu(C.sub.3 H.sub.5 OS.sub.2).sub.2).
A method for formulating a sucrose sulfate composition, useful for in vivo administration to a patient as an image contrast agent for selective identification of diseased sistes in the gastrointestinal tract by magnetic resonance imaging, comprising the following steps:
- a) labeling a sucrose sulfate with at least one member selected from the group consisting of paramagnetic ions, superparamagnetic particles, and ferromagnetic particles, to form a labeled sucrose sulfate;
- and
- b) isolating said labeled sucrose sulfate in a medium suitable for in vivo administration to a patient.
A method for detecting gastrointestinal disease in a patient comprising the following steps:
- a) administering a diagnostically effective amount of a composition comprising a course sulfate labeled with at least one member selected from the group consisting of paramagnetic ions, superparamagnetic particles, and ferromagnetic particles;
- b) administering the composition in vivo to the patient;
- and
- c) a subjecting the patient to magnetic resonance imaging.
Dependencies are inferred from the claim text.