Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
AssigneeNeoRx Corporation
InventorAnanthachari Srinivasan
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Abstract
Chelating compounds which comprise one or more sulfur atoms and are to be radiolabeled with metal radionuclides to form the corresponding chelates are disclosed. The chelating compounds comprise thioacetal or hemithioacetal sulfur protecting groups which are displaced during the radiolabeling reaction, which is conducted at acidic pH, such that bonds form between said sulfur atoms and said radionuclide. The resulting metal radionuclide chelates have diagnostic and therapeutic medical uses.
Claims20
A method of producing a radionuclide metal chelate, comprising reacting a radionuclide metal with a chelating compound under conditions of acidic pH, thereby producing said radionuclide metal chelate, wherein said chelating compound comprises one or more sulfur donor atoms attached to a protecting group, and said protecting group, when taken together with the one or more sulfur donor atoms attached thereto, is a hemithioacetal group or a thioacetal group.
Dependencies are inferred from the claim text.