Human squamous lung carcinoma cell specific antigens and antibodies
OwnerLennart Olssoninventor
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Abstract
Methods and compositions are provided for detecting antigens having a specific epitope associated with squamous lung carcinoma. The antigen may be found at lesion sites or in the blood as indicative of the squamous lung carcinoma. Specific antibodies may be used for the detection of the antigen and in therapy. The mouse hybridoma 43-9F producing IgM monoclonal antibody 43-9F and SLC cell RH-SLC-L11 were deposited at The PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, U.K. on Jan. 31, 1985 and given Accession Nos. 85013101 and 85061403, respectively.
Claims27
A monoclonal antibody specific for a glycoprotein which is a marker for human squamous lung carcinoma, where the marker is a carbohydrate sequence found on a plurality of glycoproteins in excess of about 50kDal and substantially absent in (1) carcinomas of organs other than lung, (2) leukemias and (3) sarcomas;
- and wherein said monoclonal antibody specific for a glycoprotein binds to the saccharide portion of said glycoprotein which is recognized specifically by IgM monoclonal antibody designated 43-9F secreted by hybridoma cell line having deposit no. ECACC 85013101.
An IgM monoclonal antibody designated 43-9F secreted by a hybridoma cell line having deposit no. ECACC 85013101.
Dependencies are inferred from the claim text.