Method of targeting tumors in humans
AssigneeVestar, Inc.
InventorsCary A. Presant, Richard T. Proffitt
Life of this patent
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Abstract
A method is provided for delivering micellular particles containing a radiolabelled marker to tumors within humans. The micellular particles are less than approximately 2000.ANG. and incorporate essentially chemically pure phospholipid molecules in their external surface. Human patients given intravenous injections of such radiolabelled micellular particles showed tumors imaged by such method, without developing symptoms related to the micellular particles.
Claims14
A method of targeting tumors in the breast, lung, prostate, kidney, colon, lymph, bone, lymph node, soft tissue including mediastinum, liver and spinal cord in humans comprising providing small umilamellar vesicles of less than about 2000.ANG. comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive or chemotherapeutic agent into said vesicles and introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor for treating and/or imaging said tumor.
A method of targeting and imaging tumors in the breast, lung, prostate, kidney, colon or lymph of humans, comprising providing small unilamellar vesicles of less than about 2,000 .ANG. comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
A method of targeting and imaging bone, lymph node, soft tissue including mediastinum, lung, liver and spinal cord in humans for the presence of tumors, comprising providing small unilamellar vesicles of less than about 2,000 .ANG. comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
A method of targeting and imaging metastatic tumors in humans, comprising providing small unilamellar vesicles of less than about 2,000 .ANG. comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
A method of targeting and imaging metastatic tumors arising from a primary breast cancer, oat cell carcinoma, prostatic carcinoma, renal cell carcinoma, colon carcinoma or malignant lymphoma in humans, comprising providing small unilamellar vesicles of less than about 2,000 .ANG. comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Dependencies are inferred from the claim text.