Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
AssigneeThe Trustees of Columbia University in the City of New York
InventorsCharles L. Fox, Jr., Shanta M. Modak, Lester A. Sampath
Life of this patent
Estimating the term…
Abstract
A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine (or its salts); also disclosed are medical devices having the synergistic composition therein or compositions thereon.
Claims67
A method for making an infection-resistant material comprising incorporating an effective amount of an antimicrobial agent in a matrix comprising a polymeric component selected from the group consisting of biomedical polyurethanes, biomedical silicones, biodegradable polymers and combinations thereof, wherein the matrix is effective to provide controlled release of the antimicrobial agent at a level sufficient to suppress infection when in contact with fluids, and wherein the antimicrobial agent includes synergistically effective amounts of a silver salt and a biguanide.
A method of preparing an infection-resistant article comprising the steps of
- (a) dispersing an effective amount of an antimicrobial agent and a matrix forming polymeric material selected from the group consisting of biomedical polyurethanes, biomedical silicones, biodegradable polymers and combinations thereof in a solvent to form a first coating vehicle;
- (b) applying the first coating vehicle to the article to form a first coating and;
- (c) preparing a second coating vehicle and applying said second coating vehicle to the coated article to form a second coating thereon.
A method of preparing an infection-resistant article comprising incorporating into the article an effective amount of an infection-resistant material in a matrix, the matrix comprising a polymeric component selected from the group consisting of biomedical polyurethanes, biomedical silicones, biodegradable polymers and combinations thereof and an antimicrobial agent, wherein the matrix is effective to provide controlled release of the antimicrobial agent at a level sufficient to suppress infection when in contact with fluids, and wherein the antimicrobial agent includes synergistically effective amounts of a silver salt and a biguanide.
A method of preparing an infection-resistant medical device which comprises:
- (a) preparing a mixture of silver or a silver salt and a biguanide in effective amounts;
- and
- (b) applying said mixture as a coating to a surface of the medical device, such that upon exposure to a fluid, the silver or its salt and the biguanide are released in synergistic infection-resistant amounts.
An infection-resistant medical device comprising an effective amount of an antimicrobial agent comprising silver or a salt thereof and a biguanide in synergistically effective amounts.
An expanded PTFE vascular graft, a substantial proportion of the interstices of which contains a coating composition comprising, by weight, one part biomedical polyurethane, one part poly(lactic acid), one part chlorhexidine acetate, and three parts pipracil.
Dependencies are inferred from the claim text.