Carboxyalkyl dipeptides as antiglaucoma agents

A method for reducing and/or controlling elevated intraocular pressure in a mammal which comprises topically administering to an eye of said mammal a composition comprising the combination of an anti-inflammatory amount of an anti-inflammatory steroid an intraocular pressure reducing effective amount of a compound represented by the formulae:

• ##STR9## or their isomers or pharmaceutically acceptable salts thereof, in combination with an ophthamologically acceptable carrier for topical use, wherein ##STR10## R.sup.1 is hydrogen or lower alkyl;
• R.sup.2 and R.sup.5 are independently hydrogen, lower alkyl, phenyl, or phenyl(lower)alkyl;
• R.sup.3 and R.sup.4 are independently hydrogen, lower alkyl, haloloweralkyl, phenyl, or phenyl(lower)alkyl, or R.sup.3 and R.sup.4 taken together with the carbon to which they are attached can form a 5-7 membered cycloalkyl ring;
• R.sup.6 and R.sup.8 are independently hydroxy, alkoxy having from 1 to 8 carbon atoms, L--Q.sub.r --(CH.sub.2).sub.s --O--, wherein L is phenyl, substituted phenyl, 1- naphthyl or 2-naphthyl;
• Q is oxygen or sulfur;
• r is 0 or 1 and s is 0 to 4;
• and wherein the substituents on the phenyl are chosen from group M, wherein M is halogen, hydroxy, trifluoromethyl, alkoxy having from 1 to 6 carbon atoms, alkyl from 1 to 6 carbon atoms, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl and phenyl (which phenyl group may be substituted with halogen, hydroxy, trifluoromethyl, alkoxy having from 1 to 6 carbon atoms or alkyl having from 1 to 6 carbon atoms);
• provided that when s is zero,
• r is zero;
• --OCH.sub.2 --OCO--alkyl wherein the alkyl has from 3 to 8 carbon atoms, --OCH.sub.2 CO--phenyl, wherein the phenyl may be substituted ##STR11## with group M, 1-gylceryl, R.sup.7 is hydrogen, lower alkyl, or aminoloweralkyl;
• R.sup.9 is hydrogen, lower alkyl, unsubstituted or substituted phenyl, and substituted or unsubstituted phenyl lower alkyl, wherein phenyl may be substituted by group M;
• R.sup.10 is hydrogen or lower alkyl;
• a is 0-8;
• b is 1-8;
• c is 2-8;
• m is 1-4;
• n is 0 or 1;
• p and q are each 0, 1 or 2, provided that in formulae IIIb and IIIc the sum of p and q is 1 or 2, and that in formulae IIId, p is not 0.