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US 5,017,487 AGranted
Vaccinia DNA
AssigneeHoffmann-La Roche Inc.
InventorsHendrik G. Stunnenberg, Riccardo Wittek
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Abstract
New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5' flanking region of the vaccinia virus late 11 kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such transcriptional regulatory sequences operatively linked to foreign genes, and live vaccines based upon these recombinant infectious poxviruses.
Claims38
A transcriptional regulatory sequence capable of functioning as a poxvirus late promoter selected from the group consisting of:
- (a) the sequence:
- ##STR7## (b) the sequence:
- ##STR8## and (c) the sequence:
- ##STR9##
1 more element
Dependencies are inferred from the claim text.