Multi-unit pulsatile delivery system
AssigneeAlza Corporation
InventorsFrederick Maruyama, Richard Cortese
Life of this patent
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Abstract
The present invention is directed to an active agent dispenser for use in a fluid-containing environment, which dispenser comprises a rigid housing, a plurality of movable active agent units filling a portion of the housing, a fluid-activated driving member for dispensing the active agent units filling the remainder of the housing, and an active agent unit outlet means. In the present invention, each active agent unit is comprised of an active agent dosage or filling contained within a fluid-impermeable cup-shaped member, the cup-shaped members being oriented within the housing with the base of the cup-shaped members facing the outlet means.
Claims23
An active agent dispenser for use in a fluid-containing environment comprising, in combination:
- a. a rigid housing open at one end to provide outlet means therefor, at least a portion of said housing proximate the end of said housing opposite said outlet means permitting passage of the fluid in said environment to the interior of said housing;
- b. a fluid-activated driving member within said housing in fluid-transmitting relationship with said fluid-passing portion of said housing proximate the end of said housing opposite said outlet means, said driving member, upon exposure of said dispenser to said fluid environment, being the source of motive power for moving the contents of said housing through said outlet;
- and
- c. a plurality of discrete active agent dosage units, each unit comprising:
- (i) a fluid-impermeable cup-shaped member, and
- (ii) an active agent filling contained within said cup-shaped member, wherein said active agent dosage units are longitudinally disposed within said housing between said driving member and said outlet means and are oriented within said housing with the base of said cup-shaped members facing said outlet means;
- whereby said active agent dosage units will be sequentially displaced from said housing into said fluid environment by said driving member upon exposure of said dispenser to said fluid environment, said active agent dosage units dispensing their active agent content into said fluid environment after their displacement from said housing into said environment.
An active agent dispenser for use in the rumen of a ruminant, the dispenser comprising, in combination:
- a. a rigid housing open at one end to provide outlet means therefor, at least a portion of said housing proximate the end of said housing opposite said outlet means permitting passage of the fluid in said environment to the interior of said housing;
- b. a fluid-activated driving member within said housing in fluid-transmitting relationship with said fluid-passing portion of said housing proximate the end of said housing opposite said outlet means, said driving member, upon exposure of said dispenser to said fluid environment, being the source of motive power for moving the contents of said housing through said outlet;
- c. a density element within said housing;
- and
- d. a plurality of discrete active agent dosage units, each unit comprising:
- (i) a fluid-impermeable cup-shaped member, and
- (ii) an active agent filling contained within said cup-shaped member, wherein said active agent dosage units are longitudinally disposed within said housing between said driving member and said outlet means and are oriented within said housing with the base of said cup-shaped members facing said outlet means;
- whereby said active agent dosage units will be sequentially displaced from said housing into said fluid environment by said driving member upon exposure of said dispenser to said fluid environment, said active agent dosage units dispensing their active agent content into said fluid environment after their displacement from said housing into said environment.
Dependencies are inferred from the claim text.