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US 5,015,462 AGranted
Stable stannous chloride composition for labeling with radioactive technetium
AssigneeNihon Medi-Physics Co., Ltd.
InventorsMakoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Abstract
A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
Claims3
A process for labelling red blood cells with 99m-technetium, which comprises the steps of
- (a) dissolving a dry, solid, reductive composition in water to form a resultant solution;
- said dry, solid, reductive composition being prepared by forming an aqueous solution containing stannous chloride in a concentration of not less than 0.5 mol/liter by dissolving stannous chloride alone in an aqueous solvent, charging an amount of not more than 500 microliters of said aqueous solution into a container and lyophilizing the charged aqueous solution in said container,
- (b) intravenously administering said resultant solution into a mammalian body, and
- (c) subsequently intravenously administering 99m-technetium in a pertechnetate form into said body.
1 more element
Dependencies are inferred from the claim text.