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US 5,013,649 AGranted
DNA sequences encoding osteoinductive products
AssigneeGenetics Institute, Inc.
InventorsElizabeth A. Wang, John M. Wozney, Vicki Rosen
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Abstract
Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
Claims7
An isolated DNA sequence encoding an osteoinductive protein said DNA sequence comprising a coding sequence selected from the group consisting of
- (a) nucleotide #1 through nucleotide #387 of figure I,
- (b) nucleotide #356 through nucleotide #1543 of figure II,
- (c) Nucleotide #402 through nucleotide #1626 of figure III,
- (d) naturally occurring allelic sequences and equivalent degenerative codon sequences of (a), (b), and (c);
- and
- (e) sequences which
- (1) hybridize to any of sequences (a), (b), (c), or (d) under stringent hybridization conditions;
- and
- (2) encode a protein characterized by the ability to induce the formation of bone and/or cartilage.
6 more elements
Dependencies are inferred from the claim text.