Microbially-stable bismuth-containing liquid pharmaceutical suspensions
AssigneeThe Procter & Gamble Company
InventorsLaura L. Stentz, Jerry R. Maney, Thomas E. Sox
Life of this patent
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Abstract
Microbially-stable liquid pharmaceutical suspensions for oral administration comprising a bismuth-containing pharmaceutical agent, benzoic acid, sorbic acid, a suspension system and water, and wherein said compositions have a pH within the range of from about 3.0 to about 5.5. These compositions are efficacious, and have good aesthetics and good storage stability.
Claims15
Microbially-stable liquid pharmaceutical suspensions for oral administration comprising:
- (a) from about 0.1% to about 10% of a bismuth-containing pharmaceutical agent;
- (b) from about 0.01% to about 0.075% of benzoic acid;
- (c) from about 0.01% to about 0.04% of sorbic acid;
- (d) from about 0.1% to about 10% of a suspension system;
- and
- (e) from about 80% to about 99% water, and wherein further said liquid composition has a pH within the range of from about 3.0 to about 5.5.
Microbially-stable liquid pharmaceutical suspensions for oral administration comprising:
- (a) from about 0.5% to about 5% of a bismuth-containing pharmaceutical agent selected from the group consisting of bismuth subcitrate, bismuth subsalicylate, and mixtures thereof;
- (b) from about 0.01% to about 0.06% of benzoic acid;
- (c) from about 0.01% to about 0.03% of sorbic acid;
- (d) from about 0.5% to about 5% of a suspension system selected from the group consisting of non-ionic cellulose ether polymer, magnesium aluminum silicate, and mixtures thereof;
- and
- (e) from about 90% to about 99% water, and wherein further said liquid composition has a pH within the range of from about 3.0 to about 4.2.
Microbially-stable liquid pharmaceutical suspensions for oral administration comprising:
- (a) from about 1% to about 4% of a bismuth-containing pharmaceutical agent selected from the group consisting of bismuth subcitrate, bismuth subsalicylate, and mixtures thereof;
- (b) from about 0.025% to about 0.05% of benzoic acid;
- (c) from about 0.0125% to about 0.025% of sorbic acid;
- (d) from about 1% to about 3% of a suspension system, wherein said suspension system comprises methylcellulose and magnesium aluminum silicate;
- and
- (e) from about 93% to about 98% water, and wherein further said liquid composition has a pH within the range of from about 3.0 to about 4.2.
Dependencies are inferred from the claim text.