Opthalmic fluid dispensing method
AssigneeDow Corning Corporation
InventorsRichard L. Gettings, William C. White
Life of this patent
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Abstract
A method and device for dispensing an aqueous fluid which is desired to be maintained in a sterile condition. The method includes storing a quantity of aqueous fluid such as ophthalmic saline solution in a reservoir within a portable container having an outlet. A porous filter medium is arranged within the container adjacent the outlet, and the aqueous ophthalmic fluid is caused to pass from the reservoir through the porous medium and to the outlet. The porous medium has covalently bonded thereto an antimicrobially effective amount of an organosilicon quaternary ammonium compound which is an organosilane. The organosilane can also be bonded to the inner and outer surfaces of the portable container.
Claims40
A method of dispensing an aqueous sterile fluid comprising storing a quantity of aqueous sterile fluid in a reservoir within a portable container having an outlet, arranging a porous filter medium within the container adjacent the outlet, and causing the aqueous sterile fluid to pass from the reservoir through the porous medium to the outlet, the porous medium having covalently bonded thereto an antimicrobially effective amount of an organosilicon quaternary ammonium compound, the organosilicon quaternary ammonium compound being an organosilane having the formula selected from the group consisting of consisting of ##STR8## wherein, in each formula, Y is R or RO where each R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;
- a has a value of 0, 1 or 2;
- R' is a methyl or ethyl radical;
- R'' is an alkylene group of 1 to 4 carbon atoms;
- R''', R'''' and R.sup.V are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 OH, and --(CH.sub.2).sub.x NHC(O)R.sup.vi, wherein x has a value of from 2 to 10 and R.sup.vi is a perfluoroalkyl radical having from 1 to 12 carbon atoms;
- and
- X is chloride, bromide, fluoride, iodide, acetate or tosylate.
A device for dispensing an aqueous sterile fluid comprising a portable container having a reservoir in communication with an outlet, a porous filter medium within the container adjacent the outlet, the aqueous sterile fluid passing from the reservoir through the porous medium to the outlet, the pourous medium having covalently bonded thereto an antimicrobially effective amount of an organosilicon quaternary ammonium compound, the organosilicon quaternary ammonium compound being an organosilane having the forumla selected from the group consisting of ##STR12## wherein, in each formula, Y is R or RO where each R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;
- a has a value of 0, 1 or 2;
- R' is a methyl or ethyl radical;
- R'' is an alkylene group of 1 to 4 carbon atoms;
- R''', R'''' and R.sup.v are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 CH.sub.2 OH, .dbd.CH.sub.2 OH, and --(CH.sub.2).sub.x NHC(O)R.sup.vi, wherein x has a value of from 2 to 10 and R.sup.vi is a perfluoroalkyl radical having from 1 to 12 carbon atoms;
- and
- X is chloride, bromide, fluoride, iodide, acetate or tosylate.
Dependencies are inferred from the claim text.