Dideoxyinosine by enzymatic deamination of dideoxyadenosine
AssigneeBristol-Myers Squibb Company
InventorsVittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
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Abstract
A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.
Claims3
An improved method for selectively producing .beta.-(D)-2',3'-dideoxyinosine which comprises treatment of an .alpha.-and .beta.-anomeric mixture of (D)-2',3'-dideoxyadenosine with adenosine deaminase while monitoring conversion of the preferantially deaminated .beta.-anomer to control reduction time and minimize .alpha.-anomer deamination thereby maximizing production of .beta.-(D)-2'-3'-dideoxyinosine which is recovered from the enzymatic reaction mixture.
Dependencies are inferred from the claim text.