Method to directly radiolabel antibodies for diagnostic imaging and therapy
AssigneeThomas Jefferson University
InventorMathew L. Thakur
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Abstract
The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.
Claims20
A method for directly labeling proteins with radionuclides for use in diagnostic imaging and therapy comprising the steps of incubating a protein-containing solution with a solution of sodium ascorbate;
- adding a required quantity of reduced radionuclide to said incubated protein-containing solution and incubating.
Dependencies are inferred from the claim text.