2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
AssigneeBioCryst, Inc.
InventorsJohn A. Secrist, III, John A. Montgomery, Steve E. Ealick, Mark D. Erion, Wayne C. Guida
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Abstract
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
Claims19
A compound of the formula 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is optionally substituted by halogen, hydroxy, alkoxy, alkyl or trifluoromethyl.
Dependencies are inferred from the claim text.