2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
AssigneeBioCryst, Inc.
InventorsJohn A. Secrist, III, John A. Montgomery, Steve E. Ealick, Mark D. Erion, Wayne C. Guida
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Abstract
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted alicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
Claims13
A compound of the formula 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is a cycloolefin or cycloparafin having up to nine carbon atoms in the ring structure which can be optionally substituted with at least one of halogen, hydroxy, alkoxy, alkyl, or trifluoromethyl.
Dependencies are inferred from the claim text.