Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
AssigneeSalutar, Inc.
InventorsSteven C. Quay, Scott M. Rocklage, Warren K. Miller
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Abstract
The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects or the invention.
Claims23
An amyloid binding diazo compound of Formula III or Formula IV or a water-soluble non-toxic salt thereof:
- ##STR13## wherein:
- I.sup.* is a radioactive iodine moiety;
- R.sub.40 R.sub.41 are hydrogen hydroxy or amino, and R.sub.40 and R.sub.41 are not the same group;
- R.sub.42, R.sub.43, R.sub.44, R.sub.45 and R.sub.46 are sulfo;
- and sulfo is not present on adjacent carbons;
- and
- R.sub.47 is hydrogen, methyl or carboxy.
A method for determining the presence and location of an amyloid deposit in a body area of a patient comprising intravenous administration of an imaging effective quantity of a compound containing a radioactive iodine group of any one of claims 16, 18, 19 or 24 to the patient, and sensing radiation emitted from the body area.
A method for determining the presence and location of an amyloid deposit in a body area of a patient comprising intravenous administration of an imaging effective quantity of a compound containing a radioactive iodine group of anyone of claims 16-22 inclusive to the patient, and sensing radiation emitted from the body area.
4-Amino-3-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-3-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-3-(1-.sup.125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-6-(1-.sup.125 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-63-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-6-(1-.sup.125 I-phen-4-yldiazo-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
1-Amino-8-hydroxy-7-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
1-Amino-8-hydroxy-7-(1-.sup.125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
1-Amino-8-hydroxy-2-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
1-Amino-8-hydroxy-2-(1-.sup.125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.123 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.125 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.123 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-.sup.125 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-carboxy-3-.sup.123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-3-(1-carboxy-3-.sup.125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
4-Amino-5-hydroxy-3-(1-.sup.123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Dependencies are inferred from the claim text.