Chroman esters of phenols and benzoic acids having retinoid-like activity
AssigneeAllergan, Inc.
InventorRoshantha A. S. Chandraratna
Life of this patent
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AssigneeAllergan, Inc.
InventorRoshantha A. S. Chandraratna
Estimating the term…
Retinoid like activity is exhibited by compounds of the formula ##STR1## wherein the R.sub.1 -R.sub.7 groups are independently H or straight chain or branched chain lower alkyl or cycloalkyl of 1 to 6 carbons; X symbolizes an ester or thioester linkage, Y is cycloalkyl or branched chain alkyl of 1 to 6 carbons or is (CH.sub.2) where n is an integer between 0 to 6 or is an alkenyl group of 2 to 6 carbons, or an alkynyl group of 2 to 6 carbons; and Z is H, OH, OR', OCOR', --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR' or a ketal derivative where R' is an alkyl, cycloalkyl or alkenyl group containing 1 to 6 carbons, or a phenylalkyl, phenyl or substituted phenyl group.
A compound of the formula ##STR14## wherein the R.sub.1 -R.sub.7 groups are independently H or straight chain lower alkyl group of 1 to 6 carbons or branched chain lower alkyl or cycloalkyl groups of 3 to 6 carbons;
A compound of the formula ##STR15## wherein the R.sub.1 -R.sub.7 groups are independently H or straight chain alkyl group of 1 to 6 carbons or branched chain lower alkyl or cycloalkyl groups of 3 to 6 carbons;
A compound of the formula ##STR16## wherein the R.sub.1 -R.sub.4 groups are independently H or CH.sub.3, the R.sub.5 -R.sub.6 groups are independently H or lower alkyl of 1-6 carbons, and R.sub.10 is OR* where R* is H, lower alkyl, or R.sub.10 is N(R**).sub.2 where R** independently is H or lower alkyl.
Dependencies are inferred from the claim text.