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US 5,006,530 AGranted
Certain 7-[2,6-diisopropyl-4-phenyl-5-lower alkoxymethyl-pyrid-3-yl]-3,5-dihydroxy-6-enoates and derivatives useful for treating circulatory diseases
AssigneeBayer Aktiengesellschaft
InventorsRolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Abstract
Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings, X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and R is ##STR2## wherein R.sup.21 denotes hydrogen or alkyl and R.sup.22 denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products.
Claims19
A substituted pyridine of the formula ##STR217## in which B and E are C.sub.1-3 -alkyl of which one may be cyclopropyl,
- Y--Q-- is CH.sub.3 O--, (H.sub.3 C).sub.3 C(CH.sub.3).sub.2 --Si--O--, ##STR218## C.sub.2 H.sub.5 O--, C.sub.3 H.sub.7 O--, i-C.sub.3 H.sub.7 O--, C.sub.4 H.sub.9 O--, C.sub.5 H.sub.11 --, C.sub.6 H.sub.13 O-- or ##STR219## and R.sup.22 is hydrogen, lower alkyl, phenyl, benzyl or a physiologically tolerable metal or ammonium cation.
Dependencies are inferred from the claim text.