Pulmonary administration of pharmaceutically active substances
OwnerBradley J. Benson, JoRae Wrightinventors
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Abstract
Pulmonary administration of a pharmaceutically active substance useful for local or systemic action which comprises, liposomes containing an effective amount of a pharmaceutically active substance, and an amount of alveolar surfactant protein effective to enhance transport of the liposomes across a pulmonary surface.
Claims9
A composition for pulmonary administration of a pharmaceutically active substance, said composition comprising 60-90% by weight liposome forming compound, 5-20% by weight pharmacentically active substance, and 5-20% by weight surfactant protein, based on the total weight of liposome-forming substance, pharmacentically active substance and alveolar surfactant protein, wherein said composition comprises liposomes.
A method of administering a pharmaceutically active substance which comprises applying to pulmonary surfaces for transport across said surfaces a composition comprising:
- (a) liposomes formed from at least one liposome-forming compound, said liposomes containing an effective amount of a pharmaceutically active substance;
- and
- (b) alveolar surfactant protein in an amount effective to enhance transport of said liposomes across a pulmonary surface.
A method of preparing a composition for delivering a pharmaceutically active substance comprising:
- (a) forming liposomes containing at least one liposome-forming compound and an effective amount of a pharmaceutically active substance;
- and
- (b) adding alveolar surfactant protein in an amount effective to enhance transport of said liposomes across a pulmonary surface.
Dependencies are inferred from the claim text.