Improvements in redox systems for brain-targeted drug delivery
AssigneeUniversity of Florida
InventorNicholas S. Bodor
Life of this patent
Estimating the term…
Abstract
Inclusion complexes of hydroxypropyl-.beta.-cyclodextrin with the reduced biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine.revreaction.pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The reodox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.
Claims48
A method for stabilizing the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal dihydropyridine form of a dihydropyridine .revreaction. pyridinium salt redox system for brain-targeted drug delivery, said method comprising complexing said dihydropyridine form with hydroxypropyl-.beta.-cyclodextrin.
A method for decreasing initial lung concentrations of drug resulting from administration of the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal dihydropyridine form of a dihydropyridine .revreaction. pyridinium salt redox system for brain-targeted drug delivery, said method comprising administering said dihydropyridine form as its inclusion complex with hydroxypropyl-.beta.-cyclodextrin.
Dependencies are inferred from the claim text.