16-substituted androstanes and 16-substituted androstenes

A compound of the formula:

• ##STR68## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.11, R.sub.12, R.sub.13, R.sub.14 and R.sub.15 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.9 and R.sub.10 are independently lower alkyl, hydrogen or halogen;
• and
• R.sub.16 and R.sub.17 are independently hydrogen, amino, lower alkylamino, diloweralkyl amino, aminoloweralkyl, loweralkyl, aminoloweralkyl, diloweralkylamino loweralkyl, lower alkoxy, hydroxyloweralkyl, monohaloloweralkyl, dihaloloweralkyl, trihaloloweralkyl, loweralkoxy-loweralkyl, loweralkanoyl, formyl, or lower carbalkoxy;
• or
• R.sub.16 and R.sub.17 taken together with the carbon to which they are attached form a lower cycloalkyl or a cyclic ether containing 1 ring oxygen atom and up to 5 ring carbon atoms with the proviso that R.sub.16 and R.sub.17 are not hydrogen simultaneously and with the further proviso that when R.sub.1 -R.sub.15 and R.sub.17 are hydrogen, then R.sub.16 is not ethoxy.

A compound of the formula:

• ##STR69## wherein R.sub.5 and R.sub.6 are independently lower alkyl or hydrogen;
• and
• R.sub.16 and R.sub.17 are independently hydrogen, amino, lower alkylamino, diloweralkyl amino, aminoloweralkyl, loweralkyl aminoloweralkyl, diloweralkylamino loweralkyl, lower alkoxy, hydroxyloweralkyl, monohaloloweralkyl, dihaloloweralkyl, trihaloloweralkyl, loweralkoxy-loweralkyl, loweralkanoyl, formyl, lower carbalkoxy or lower alkanoyloxy;
• or
• R.sub.16 and R.sub.17 taken together with the carbon to which they are attached form a lower cycloalkyl or a cyclic ether containing 1 ring oxygen atom and up to a total of 5 ring carbon atoms with the proviso that R.sub.16 and R.sub.17 are not hydrogen simultaneously.

A compound of the formula:

• ##STR70## wherein R.sub.5 and R.sub.6 are independently lower alkyl or hydrogen;
• and
• R.sub.16 and R.sub.17 are independently hydrogen, amino, lower alkylamino, diloweralkyl amino, aminoloweralkyl, loweralkyl, aminoloweralkyl, diloweralkylamino loweralkyl, lower alkoxy, hydroxyloweralkyl, monohaloloweralkyl, dihaloloweralkyl, trihaloloweralkyl, loweralkoxy-loweralkyl, loweralkanoyl, formyl, lower carbalkoxy;
• or
• R.sub.16 and R.sub.17 taken together with the carbon to which they are attached form a lower cycloalkyl or a cyclic ether containing 1 ring oxygen atom and up to 5 ring carbon atoms with the proviso that R.sub.16 and R.sub.17 are not hydrogen simultaneously and with the further proviso that when R.sub.1 -R.sub.15 and R.sub.17 are hydrogen, then R.sub.16 is not ethoxy.

A compound of the formula:

• ##STR71## wherein R.sub.5 is loweralkyl or hydrogen;
• and
• R.sub.16 and R.sub.17 are independently hydrogen, amino, lower alkylamino, diloweralkyl amino, aminoloweralkyl, loweralkyl, aminoloweralkyl, diloweralkylamino loweralkyl, lower alkoxy, hydroxyloweralkyl, monohaloloweralkyl, dihaloloweralkyl, trihaloloweralkyl, loweralkoxy-loweralkyl, loweralkanoyl, formyl, lower carbalkoxy or lower alkanoyloxy;
• or
• R.sub.16 and R.sub.17 taken together with the carbon to which they are attached form a lower cycloalkyl or a cyclic ether containing 1 ring oxygen atom and up to 5 ring carbon atoms with the proviso that R.sub.16 and R.sub.17 are not hydrogen simultaneously.

A compound of the formula:

• ##STR72## wherein R.sub.5 is loweralkyl or hydrogen;
• and
• R.sub.16 and R.sub.17 are independently hydrogen, amino, lower alkylamino, diloweralkyl amino, aminoloweralkyl, loweralkyl, aminoloweralkyl, diloweralkylamino loweralkyl, lower alkoxy, hydroxyloweralkyl, monohaloloweralkyl, dihaloloweralkyl, trihaloloweralkyl, loweralkoxy-loweralkyl, loweralkanoyl, formyl, or lower carbalkoxy;
• or
• R.sub.16 and R.sub.17 taken together with the carbon to which they are attached form a lower cycloalkyl or a cyclic ether containing 1 ring oxygen atom and up to 5 ring carbon atoms with the proviso that R.sub.16 and R.sub.17 are not hydrogen simultaneously, and with the further proviso that when R.sub.5 and R.sub.17 are hydrogen, then R.sub.16 is not ethoxy.