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AssigneesNew England Medical Center, Tufts College, Wellesley College, Mit
InventorsPhilip E. Auron, Andrew C. Webb, Lee Gehrke, Charles A. Dinarello, Lanny J. Rosenwasser, Alexander Rich, Sheldon M. Wolff
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The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
A recombinant DNA cloning vehicle comprising cDNA coding for truncated human IL-1 protein of the amino acid sequence:
A recombinant DNA cloning vehicle comprising cDNA coding for the amino acid sequence:
The recombinant plasmid pcD-415.DELTA.Pvu/Xmn.
cDNA coding for a truncated human IL-1 protein having the sequence ##STR3##
Bacteria transformed by the recombinant plasmid pcD-415.DELTA.Pvu/Xmn.
cDNA coding for a truncated human IL-1 protein having the sequence ##STR4## LEU GLN ASN SER ILE TRP THR GLY VAL LEU SER LEU ASN GLN VAL LEU.
Dependencies are inferred from the claim text.