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AssigneeThe Board of Trustees of the Leland Stanford Jr. University
InventorsLawrence Steinman, Jorge R. Oksenberg, Gary K. Schoolnik, Amrit K. Judd
Estimating the term…
A novel method of defining oligopeptides is provided for determining useful immunodominant sequences for use as vaccines for pathogens. The method involves identifying sequences by particular selection procedures and using such sequences with antigen-presenting cells and T-cells to demonstrate activation of the common histocompatibility antigens DQ and DR in humans and their analogs in other animals. The oligopeptides may then be used individually or in combination to produce safe and effective vaccines, where genes may be prepared encoding the oligopeptides and used for expression of the oligopeptides or combinations of the oligopeptides or the gene transformed into the appropriate host, e.g., B. pertussis, for use as a vaccine to the intact organism.
A polypeptide useful as a B. pertussis vaccine comprising at least one oligopeptide comprising at least about 80% of at least one of the following sequences of the S1 subunit which are substantially free of intervening amino acid sequences of the S1 subunit wherein the sequence 44-54, 64-75, 87-98, 104-116, 206-218, 133-146, 151-161, 169-179, 180-190, and 223-233,
Dependencies are inferred from the claim text.