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US 4,999,377 AGranted
Chemical compounds
AssigneeImperial Chemical Industries PLC
InventorsPeter W. R. Caulkett, Michael J. Cooper, Murdoch Eakin, Geraint Jones
Life of this patent
Estimating the term…
Abstract
2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide compounds are disclosed as useful in the treatment of obesity and related conditions. Processes for their preparation are described, as are novel intermediates and pharmaceutical compositions containing them.
Claims12
A compound of the formula (I):
- ##STR14## wherein:
- R.sup.1 is hydrogen;
- fluoro or chloro;
- R.sup.2 is hydrogen;
- C.sub.1-6 alkyl;
- C.sub.1-6 alkyl substituted by a group selected from hydroxy, C.sub.1-4 alkoxy, phenoxy, carbamoyl, C.sub.1-6 alkylcarbamoyl, di-C.sub.1-6 alkylcarbamoyl, phenyl and chlorophenyl;
- C.sub.3-6 alkenyl;
- C.sub.3-6 alkenyl substituted by a group selected from hydroxy, C.sub.1-4 alkoxy, phenoxy, carbamoyl, C.sub.1-6 alkylcarbamoyl, di-C.sub.1-6 alkylcarbamoyl, phenyl and chlorophenyl;
- C.sub.3-6 alkynyl;
- C.sub.3-5 cycloalkyl;
- phenyl or phenyl substituted by a radical selected from halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, cyano and nitro;
- R.sup.3 is hydrogen;
- C.sub.1-6 alkyl;
- or is a group --OR.sup.4 wherein R.sup.4 is hydrogen;
- C.sub.1-6 alkyl;
- C.sub.1-6 alkyl substituted by hydroxy;
- C.sub.1-6 alkyl substituted by C.sub.1-4 alkoxy;
- C.sub.3-6 alkenyl;
- C.sub.3-6 alkenyl substituted by hydroxy;
- C.sub.3-6 alkenyl substituted by C.sub.1-4 alkoxy;
- or R.sup.4 is C.sub.3-6 alkynyl, phenyl, naphthyl, phenyl C.sub.1-4 alkyl or naphthyl C.sub.1-4 alkyl;
- or a pharmaceutically acceptable salt thereof.
19 more elements
A compound of the formula (IX):
- ##STR15## wherein:
- R.sup.1 is hydrogen;
- fluoro or chloro;
- R.sup.2 is hydrogen;
- C.sub.1-6 alkyl;
- C.sub.1-6 alkyl substituted by a group selected from hydroxy, C.sub.1-4 alkoxy, phenoxy, carbamoyl, C.sub.1-6 alkylcarbamoyl, di-C.sub.1-6 alkylcarbamoyl, phenyl and chlorophenyl;
- C.sub.3-6 alkenyl;
- C.sub.3-6 alkenyl substituted by a group selected from hydroxy, C.sub.1-4 alkoxy, phenoxy, carbamoyl, C.sub.1-6 alkylcarbamoyl, di-C.sub.1-6 alkylcarbamoyl, phenyl and chlorophenyl;
- C.sub.3-6 alkynyl;
- C.sub.3-5 cycloalkyl;
- phenyl or phenyl substituted by a radical selected from halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, cyano and nitro;
- R.sup.3 is hydrogen;
- C.sub.1-6 alkyl;
- or is a group --OR.sup.4 wherein R.sup.4 is hydrogen;
- C.sub.1-6 alkyl;
- C.sub.1-6 alkyl substituted by hydroxy;
- C.sub.1-6 alkyl substituted by C.sub.1-4 alkoxy;
- C.sub.3-6 alkenyl;
- C.sub.3-6 alkenyl substituted by hydroxy;
- C.sub.3-6 alkenyl substituted by C.sub.1-4 alkoxy;
- or R.sup.4 is C.sub.3-6 alkynyl, phenyl, naphthyl, phenyl C.sub.1-4 alkyl or naphthyl C.sub.1-4 alkyl;
- and
- Q is benzyl, 4-methoxybenzyl or 3,4-dimethoxybenzyl.
20 more elements
Dependencies are inferred from the claim text.